Sugar acids and derivatives
Medchemexpress LLC β-D-glucopyranosiduronic acid p-nitrophenyl carbonate derivative | 894095-98-8 | 99.6% | 913.83 g/mol | C45H43N3O18 | 1 G
β-D-glucuronide-pNP-carbonate is a glucuronide-cleavable carbonate linker used to attach payloads to antibodies for research-scale antibody-drug conjugate (ADC) synthesis. It is supplied as a purified small-molecule reagent for linker-payload assembly and analytical characterization.
- Cleavable glucuronide-based linker responsive to glycosidase cleavage.
- Reported purity around 99.6%.
- Molecular formula C45H43N3O18; molecular weight 913.83 g/mol.
- Available in small-scale packaging including 1 G; larger quantities available on request.
- Supporting documents include datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Mac glucuronide linker-1 | 2222981-71-5 | MFCD32671554 | 96.4% | 897.90 | C42H47N3O17S | 50 MG
MAC glucuronide linker-1 is a cleavable glucuronide-based linker designed for antibody-drug conjugate (ADC) research. It enables enzymatic release of payloads from antibody-payload conjugates, facilitating controlled drug release in ADC development.
- Cleavable glucuronide linker for ADCs.
- Designed for enzymatic payload release by glucuronidase.
- Suitable for antibody-agent conjugations and linker-payload development.
- Reported purity approximately 96.4% and molecular weight 897.90.
- Available in multiple pack sizes, including 50 MG.
eMolecules Medchem Express / Sesamolin / 5mg / 582658843 / HY-N0809 / / 526-07-8 / MFCD04112844 / 370.357 / C20H18O7
Medchem Express / Sesamolin / 5mg / 582658843 / HY-N0809 / / 526-07-8 / MFCD04112844 / 370.357 / C20H18O7
Medchemexpress LLC Beta-Cortol | 667-65-2 | 99.9% | 368.51 | 10 MG
Beta-Cortol is an O-glycosylated compound and a cortisol metabolite that can be isolated from the leaves of the mulberry cultivar Yu 711. Its concentration significantly decreases when the plant is subjected to drought stress. Beta-Cortol acts as a biomarker, with serum levels in early non-small cell lung cancer models showing a downregulation to 1/8 of the preoperative level after tumor resection. Due to these significant changes under specific pathological conditions, Beta-Cortol is extensively used in studies related to early non-small cell lung cancer.
- O-glycosylated compound and cortisol metabolite.
- Isolated from the leaves of mulberry cultivar Yu 711.
- Concentration decreases significantly under drought stress in plants.
- Serves as a biomarker for early non-small cell lung cancer.
- Serum levels are significantly downregulated in non-small cell lung cancer models after tumor resection.
Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | 99.5% | 568.53 | 1 MG
SN-38 glucuronide, also known as SN-38G, is an inactive metabolite of the anticancer molecule Irinotecan. It has known toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor used in research for colon and rectal cancer. SN-38 glucuronide can be reactivated by gut microbial β-glucuronidase enzymes, which remove the glucuronic acid moiety, thus increasing its toxic effects on the intestine.
- Inactive metabolite of Irinotecan.
- Has toxic effects on the gastrointestinal tract.
- Can be reactivated by gut microbial β-glucuronidase enzymes.
- Relevant in the study of colon and rectal cancer.
- Cells metabolizing SN38 to SN38-G show increased resistance to extracellular SN38.
Medchemexpress LLC CMP-Sialic acid (sodium salt) | 1007117-62-5 | 90.8% | 636.43 | 25 MG
CMP-Sialic acid sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. It provides a substrate for Golgi sialyltransferases and is an important sugar nucleotide for the biosynthesis of sialic acid and its conjugates.
- Allosteric inhibitor of UDP-GlcNAc 2-epimerase.
- Provides a substrate for Golgi sialyltransferases.
- Important sugar nucleotide for biosynthesis of sialic acid and its conjugates.
- Appearance: Solid, white to off-white.
- Can be used as a CMAH substrate to detect the formation of Neu5Gc in platelet lysates (at 22.5 μM for 45 min).
Medchemexpress LLC D-Glucuronic acid sodium monohydrate-13C6 | 207300-70-7 | 1 MG
D-Glucuronic acid sodium monohydrate-13C6 is a 13C-labeled endogenous metabolite. This compound serves as a tracer and an internal standard for various quantitative analyses.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC D-Dimannuronic acid sodium | 10 MG
D-Dimannuronic acid sodium is an alginate extract derived from brown algae. This compound is primarily used in research to synthesize sulfated polymannuronate (SPMG)-derived oligosaccharides. It is intended for research use only.
- Derived from brown algae
- Used to synthesize sulfated polymannuronate (SPMG)-derived oligosaccharides
- For research use only
- Purity of 99.94%
- Molecular weight of 392.25
- Molecular formula is C12H17NaO13
- Appears as a white to off-white solid
- Soluble in H2O at 125 mg/mL (318.67 mM), requires ultrasonic treatment
Medchemexpress LLC 4-Methylumbelliferyl-β-D-xylopyranoside | 6734-33-4 | 99.7% | 308.29 | 50 MG
4-Methylumbelliferyl-β-D-xylopyranoside (MuX) can be used as a substrate for researching β-Xylosidase activity. It exhibits burst, steady-state kinetics, supporting the conclusion that the hydrolysis of glycosidic bonds for this substrate is rapid. This product is for research use only and not sold to patients.
- Purity of 99.7%
- Initial source is animal
- Structure classification: Phenylpropanoids, Coumarins
- Used as a substrate for β-Xylosidase activity research
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Complement factor D-IN-1 | 1386455-76-0 | 98.9% | 483.32 g/mol | C21H19BrN6O3 | 25 MG
Complement factor D-IN-1 is a potent and selective reversible small-molecule inhibitor of complement factor D used in research to probe the alternative complement pathway. It exhibits low-nanomolar activity in biochemical assays and is supplied with high reported purity as a solid or as a DMSO solution.
- Potent and selective reversible inhibitor of complement factor D.
- Demonstrated low-nanomolar IC50s in FD thioesterolytic and MAC deposition assays.
- High reported purity (≈98.8%).
- Available as dry powder or as a ready-to-use DMSO solution.
- Stable when stored under recommended conditions for long-term use.
- Suitable for biochemical and cellular complement pathway studies.
Cayman Chemical D-GlucuronIc AcId 5g
A metabolite of glucose; a component of proteoglycans; levels are increased in fibroblasts isolated from patients with ISSD or Salla disease
Medchemexpress LLC D-Thyroxine | 51-49-0 | 98.0% | C15H11I4NO4 | 25 MG
D-Thyroxine (D-T4) is an orally active thyroid hormone that inhibits the secretion of TSH. It can inhibit goiter, promote metamorphosis of tadpoles, and influence cholesterol metabolism. D-Thyroxine can be used for the study of hypercholesterolemia. This product is intended for research applications only.
- Orally active thyroid hormone
- Inhibits the secretion of TSH
- Can inhibit goiter
- Promotes metamorphosis of tadpoles
- Influences cholesterol metabolism
- Used for the study of hypercholesterolemia
Medchemexpress LLC IL-1RA/IL-1F3 Porci 5ug | 5ug
IL-1RA/IL-1F3 proteins are powerful anti-inflammatory antagonists in the interleukin 1 family specifically targeting the pro-inflammatory cytokines IL1B and IL1A This protein counteracts the inflammatory effects of IL1 playing a critical role in preventing immune dysregulation and preventing uncontrolled systemic inflammation triggered by a variety of innate irritants including pathogens IL-1RA/IL-1F3 Protein Porcine is the recombinant Porcine-derived IL-1RA/IL-1F3 protein expressed by E coli with tag free
Medchemexpress LLC Glucuronic acid sodium | 7182-77-6 | 1 MG
Glucuronic acid sodium is a polysaccharide that exhibits anti-inflammatory activity, supporting the healing of ulcerative colitis. It also enhances the intestinal barrier by upregulating tight junction proteins like ZO-1 and Occludin. Additionally, it modulates gut microbiota by increasing beneficial bacterial populations while suppressing harmful ones.
- Exhibits anti-inflammatory activity
- Supports healing of ulcerative colitis
- Enhances intestinal barrier function
- Modulates gut microbiota
- Increases beneficial bacterial populations
- Suppresses harmful bacterial populations
Medchemexpress LLC Protac BET-binding moiety 2 | 916493-82-8 | 99.8% | 10 MG
Small-molecule BET bromodomain inhibitor intended as the BET-binding ligand component in PROTAC constructs and for biochemical and cell-based research applications. Supplied as a solid or as a 10 mM solution in DMSO, with reported high purity and identifying registry information for compound verification.
- Functions as a BET bromodomain ligand for PROTAC design and target engagement studies.
- Available as solid powder and as a 10 mM solution in DMSO for assay flexibility.
- High reported purity suitable for research use.
- Characterized by CAS 916493-82-8 and molecular weight 444.89 for identification.
- Provided for research use only; not for human or clinical use.